Abstract: Objectives: Behcet's disease (BD) is a multi-system disease. We present here the various clinical aspects of BD based on the data of 4586 Iranian patients. The male to female ratio was 1.17/l. The mean age at the onset of the disease was 26 yr (SD:9.6, CI:0.3). The mean disease duration was 9 yr (SD:7), and the mean follow up time was 3 yr (SD:3.8). As the first manifestation of the ...
Abstract: Objectives: The etiology and pathogenesis of Behcet's disease (BD) are still unknown. It seems that in a special genetic background exogenous or endogenous antigen(s) acts as trigger in up regulating and presenting the pathogenic epitope. The immune system reacts in an abnormal way, by inducing a cascade of cytokines and chemokines to stimulate innate immune responses, leading to the lesions of the disease. Genetic background: The major susceptibility gene is the ...
Abstract: Objectives: The ocular manifestations of Behcet's disease (BD) are very frequent involving approximately 60% of BD patients. These lesions consist mainly of uveitis (anterior, posterior, or panuveitis that are present in almost all the BD patients with ocular involvement) and necrotizing vasculitis of the retina. In a randomized survey carried on 1812 patients with Ocular-Behcet the prevalence of different ocular signs were as follow: Hypopion 8.7%, glaucoma 8.5%, cataract 70%, ...
Abstract: Purpose: Cytotoxic drugs are the main therapeutic agents. A comparative study of 8 different therapeutic methods in 1220 cases is presented here. Materials & Methods: In an open, non-randomized control study, Pulse Cyclophosphamide (PCP), low dose PCP (LDP), oral cyclophosphamide ( OCP), weakly methotrexate ( MTX), chlorambucil ( CHL), cyclosporine A ( CYA), azathioprine (AZA), and combination therapy with LDP and MTX (COM) were used. Mean Duration: Ocular manifestations in months. FU: ...